Genes frequently mutated in cutaneous melanoma include BRAF (45%–50% of tumors), CDKN2A (13%–40%), NRAS (~30%), and TP53 (15%–18%), while BRAF (10%–35%), NRAS (8%–22%), and NF1 (11%–23%) are often mutated in acral melanomas (42, 45). This evidence concerns the gene TP53 and acral lentiginous melanoma.