CEACAM8 and COVID-19: Studies that have examined neutrophil degranulation via these changes in surface phenotype have reported conflicting results, with some groups describing a SARS-CoV-2-induced increase in the expression of CD63 and CD66b (26, 122, 128) and others reporting no difference in the expression of CD11b or CD66b between neutrophils isolated from COVID-19 patients of differing disease severities and HCs (122, 132).