Referred to as low-density inflammatory band cells (LDIBs), these cells, whose circulating frequencies are significantly higher in patients with severe COVID-19 when compared to mild cases (29), exhibit spontaneous NET formation and LPS-induced pro-inflammatory cytokine production, with the generation of IL-6 and TNF-α significantly higher for LDIBs of severe COVID-19 cases when compared to mild patients (29). This evidence concerns the gene TNF and COVID-19.