Defined by a broad range of surface phenotypes that have included CD16low/highCD10-, CD15+CD10-CD66b+, CD10-CD64+, CD10-, CD10-CD16-CD66b+ or CD10lowCD101+/-, significantly increased frequencies and absolute numbers of immature neutrophils have been detected in patients with COVID-19 when compared to HCs (48, 49, 122, 126–128). The gene discussed is CEACAM8; the disease is COVID-19.