Mechanistic studies employing the hyperinsulinaemic-hypoglycaemia clamps in both healthy individuals and those with T1D and T2D, demonstrate that acute moderate hypoglycaemia initiates a pro-longed pro-inflammatory state with upregulation of C-reactive-protein (CRP), increased platelet reactivity and mobilisation of pro-inflammatory leukocyte subsets (283–286). This evidence concerns the gene CRP and type 1 diabetes mellitus.