The proportion of IL-12Rβ2+ cells did not differ significantly between healthy controls and SLE patients in all three lymphocyte subpopulations investigated i.e. CD3─CD4─ (p=0.483), CD3+CD4─ (p=0.126) and CD3+CD4+ (p=0.236) (Supplementary Figures 1A–C). This evidence concerns the gene CD4 and systemic lupus erythematosus.