CD4 and cranioectodermal dysplasia: The identification of HLA-DQ2 or HLA-DQ8 restricted CD4+ T cells in the lamina propria of CeD patients (26, 40) that preferentially recognize deamidated gluten peptides over native gluten peptides (41) stressed the connection between gluten, disease-associated HLA molecules and TG2 for the initiation of the pathogenic immune response.