IFNG and cranioectodermal dysplasia: In addition, using T84 enterocytic cell line as a model, it was shown that extracellular TG2 can be activated in a phosphatidylinositol-3-kinase-dependent mechanism by IFN-γ (50), the pro-inflammatory cytokine abundantly produced by gluten-specific T cells and released in the inflamed intestinal mucosa of CeD patients (31, 32).