Similarly, HMCL xenografts have been used to evaluate AMG 701, a half-life extended BITE that binds to BCMA on myeloma cells and CD3 on T cells (79), and to demonstrate that the therapeutic efficacy of daratumumab in myeloma may be enhanced when CD38 in NK cells has been deleted (80). This evidence concerns the gene TNFRSF17 and plasma cell myeloma.