For example, PSMB8 variant encoding a protein with lysine in position 49 (PSMB8-K) has a lower mRNA stability and a lower interferon-gamma-mediated induction than an alternative form with glutamine in this position (PSMB8-Q) and was associated with colon cancer (31). The gene discussed is PSMB8; the disease is malignant colon neoplasm.