Although it has been modelled that in states of greater IgG production, such as autoimmune disease, the efficacy of anti-FcRn therapy is likely increased (34) our speculation is plausible, since targeting FcRn-mediated IgG recycling results in the accelerated removal of IgG, but does not interfere with the production of IgG. Here, FCGRT is linked to autoimmune disease.