CD8A and type 1 diabetes mellitus: To mention a few: NOD mice fed with a fiber-rich diet had decreased T1D incidence and lower proportion of autoantigen-specific CD8+ lymphocytes in the spleen (31), supplementation with bacterial metabolite butyrate decreased severity of insulitis in NOD mice and their offspring by promoting Treg proliferation in GALT and their migration to the pancreas (32, 33), administration of probiotics exerted beneficial effects in T1D in mice (34–36).