Simultaneously, using transcriptomics data from human ESCC, we also observed that many markers for M2 macrophages such as MRC1, CD209, CD163 and TREM2 were positively correlated to PGE2 biosynthesis (suggested by PTGES and PTGS1) of arachidonic acid metabolism (Figure 6B). This evidence concerns the gene TREM2 and esophageal squamous cell carcinoma.