Simultaneously, using transcriptomics data from human ESCC, we also observed that many markers for M2 macrophages such as MRC1, CD209, CD163 and TREM2 were positively correlated to PGE2 biosynthesis (suggested by PTGES and PTGS1) of arachidonic acid metabolism (Figure 6B). The gene discussed is PTGS1; the disease is esophageal squamous cell carcinoma.