PTPN11 and Noonan syndrome: Up to date, the spectrum of genes with germline pathogenic variants associated with Noonan syndrome exceeds 20 (PTPN11, SOS1, SOS2, KRAS, NRAS, RIT1, RRAS, RASA1, RASA2, MRAS, RAF1, BRAF, MAP2K1, MAP3K8, SHOC2, PPP1CB, SPRY1, LZTR1, MYST4, A2ML1, and CBL).