Nevertheless, the involvement of Jag1-Notch signaling in thyroid organogenesis is also sustained by the enrichment in JAG1 pathogenic variants among patients with CH, and in particular in syndromic cases with thyroid dysgenesis and associated cardiac defects, as well as by the occurrence of thyroid dysfunction among young patients with Alagille syndrome (13, 77, 78). Here, JAG1 is linked to Alagille syndrome.