Studies found that menarche age was affected by various factors, including heredity, diet habits, natural environment, etc. We analyzed that patients in the PCOS-MS group were more accessible to various fat source at an early age due to the influence of heredity or diet habits, which may be a vital information for the secretion of leptin, finally stimulating the hypothalamus and leading to the oversecretion of GnRH. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.