Considering that hyperglycaemia has the potential to decrease trophoblast invasion (80), FKBPL expression was found to be reduced in high glucose conditions, but only in the presence of low oxygen levels, which suggests that physiological normal levels of FKBPL may be important in determining primary trophoblast invasion during the first trimester of pregnancy in women with diabetes. The gene discussed is FKBPL; the disease is diabetes mellitus.