Retinoic acid-related orphan receptor α (RORα) was found to mediate the induction of osteoarthritis by alterations in cholesterol metabolism, which acts as downstream receptor of cholesterol hydroxylases, including cholesterol 25-hydroxylase (CH25H) and 25-hydroxycholesterol 7α-hydroxylase (CYP7B1) (He et al., 2021). This evidence concerns the gene CH25H and osteoarthritis.