Li et al. explored the effects of DOT1L inhibitor EPZ-5676 in combination with chemotherapy drugs on the proliferation and apoptosis of human ALL cells, and they concluded that the combination of these drugs has a synergistic inhibitory effect on proliferation, and low concentrations of EPZ-5676 combined with different chemotherapy drugs cause synergistic induction of apoptosis and have pro-apoptotic effects (Li LH. The gene discussed is DOT1L; the disease is acute lymphoblastic leukemia.