TNF and rheumatoid arthritis: Based on functional enrichment analysis, these 33 genes were mainly involved in the inflammation-immune regulation module, and the purple box indicates that the pathway information was closely related to the occurrence and development of RA (Figure 5D), such as cytokine-cytokine receptor interaction, chemokine signaling pathway, TNF signaling pathway, NOD-like receptor signaling pathway, and Toll-like receptor signaling pathway.