Moreover, Heo et al. has revealed ethanol promotes the overexpression of TXNIP and the activation of NLRP3 inflammasome, thereby inducing canonical cell pyroptosis (Heo et al., 2019), whereas Khanova et al. reported that non-canonical caspase-11/GSDMD pathway but not canonical caspase-1/IL-1β pathway is activated in alcoholic hepatitis (Khanova et al., 2018). The gene discussed is CASP1; the disease is alcoholic hepatitis.