The up-regulated gene TSPAN8 in breast CSCs interacts with PTCH1 and restrains the degradation of SHH/PTCH1 compounds by recruiting the deubiquitinating enzyme ATXN3, thereby promoting the expression of stem genes NANOG, OCT4, as well as ALDHA1, which results in tumor formation, chemoresistance, and poor prognosis (Zhu et al., 2019). The gene discussed is PTCH1; the disease is neoplasm.