TGFB1 and Hepatic fibrosis: Clinical studies have also confirmed that LWWL also has definite therapeutic effects on liver fibrosis, we also demonstrated that LWWL could attenuate hepatic fibrosis via modulation of TGF-β1 and NF-κB signaling pathways in BDL and CCL4-induced hepatic fibrosis rat models (Liu et al., 2018a; Liu et al., 2018b).