The inhibitory effect of the combination of SolB and WeD on hepatic fibrosis is superior to that of individual SolB or WeD treatments in CCl4-induced liver fibrosis model mice, as evidenced by the histopathological assessment, quantitative analysis of fibrogenesis and anti-fibrinogenic genes or the expression of proteins such as collagen I and α-SMA. Here, ACTA1 is linked to Hepatic fibrosis.