TGFB1 and Hepatic fibrosis: But TGF-β1 is a multifunctional cytokine with broad biological activities involving multiple biological functions, such as embryogenesis, immunity, carcinogenesis and inflammation (Wynn and Ramalingam, 2012; Wu et al., 2017), whether long-term inhibition of TGF-β1 activity is beneficial to patients with hepatic fibrosis remains to be further studied.