Thus, we evaluated the cytoglobin by qPCR in CCl4-induced hepatic fibrosis mice, and the results showed that combination treatment of WeD and SolB significantly reduced the expression of cytoglobin induced by CCl4 in mice compared to that by treatment with WeD and SolB alone, suggesting that the combination of WeD and SolB is more effective in the treatment of liver fibrosis (Supplementary Figure S4A). This evidence concerns the gene CYGB and Hepatic fibrosis.