ACE and coronary artery disorder: At present, studies have shown that aspirin, statins, angiotensin-converting enzyme inhibitor (ACEI), angiotensin receptor blockers (ARB), and metformin can reduce the risk of vascular complications in patients with T2DM coronary heart disease (T2DM-CHD) (Holman et al., 2008; Malahfji and Mahmarian, 2018).