Moreover, TLR-9 activated plasmocytoid dendritic cells were shown to be a powerful tool for overcoming ALL resistance by NK cell-mediated killing and for reinforcing the graft versus leukemia (GvL) effect following allogeneic hematopoietic stem cell transplantation (HSCT) in an ALL mouse model of residual disease (Díaz-Rodríguez et al., 2017). This evidence concerns the gene TLR9 and leukemia.