Patient 1 was a 46-year-old male with CD-20 positive common B-ALL (Figure 1A).Genetic and molecular-genetic analysis yielded a missing chromosome, 45, XY dic (9;12) (p13;p13) in ALL blasts, plus CDKN2A and 3’ETV6 deletion. The gene discussed is ETV6; the disease is acute lymphoblastic leukemia.