KCNMA1 and Alzheimer disease: Relying on this finding, we adopted the spike broadening as an index of BK channel activity and, thereby, demonstrated that up- and down-regulation of BK channel activities are well correlated with cognitive amelioration and decline in 3xTg AD model mice, respectively, in our previous studies (Wang F. et al., 2015; Wang L. et al., 2015).