In the univariate analysis, ApoE ε4 non-carriers had a lower proportion of females than ApoE ε4 carriers, however other covariates (age, gender, MMSE score, education level, smoking status, drinking status, intensity of physical activity, hypertension, diabetes mellitus, coronary heart disease, MABP, and BMI) had no significant difference between the two groups. The gene discussed is APOE; the disease is hypertensive disorder.