Furthermore, intracellular Ca2+ signaling through inositol 1,4,5- triphosphate receptors (IP3Rs), store-operated channels (SOCs), transient receptor potential (TRP) channels, voltage-gated Ca2+ channels (VGCCs), P2 × 7 receptors, and ionotropic glutamate receptors contribute to the motility of glioma cells. The gene discussed is CISH; the disease is central nervous system cancer.