CISH and central nervous system cancer: Consistently, suppression of Ca2+ entry by SOCs inhibits glioma cell motility through the actions of proline-rich tyrosine kinase 2 (Pyk2) (Zhu et al., 2014; Zhu et al., 2020), suggesting that Ca2+ entry is significantly associated with the metastatic characteristics of GBM cells (Figure 1B).