Although most studies of TRPM8 and allodynia have been focused on the cold allodynia, the involvement of TRPM8 in mechanical allodynia has been reported in multiple inflammatory and neuropathic pain conditions (Gao et al., 2013; Caceres et al., 2017; De Caro et al., 2018). The gene discussed is TRPM8; the disease is neuropathic pain.