Previous studies have shown that Aβ oligomers and neuroinflammation associated with AD impair axonal and dendritic retromer trafficking of BDNF, causing a downregulation in neurotrophin signaling, essential for neuronal development and maintenance of dendritic complexity (Poon et al., 2011; Gan and Silverman, 2016; Seifert et al., 2016; Carlos et al., 2017; Plá et al., 2017). The gene discussed is BDNF; the disease is Alzheimer disease.