The overexpression of Kv7.2, retigabine injection in VTA, chronic treatment with fluoxetine (HCN and SK channel antagonist), or local infusion of ZD7288 have been reported to improve social behavior, reduce anxiety, increase sucrose preference, and produce antidepressive behavior in mice (Cao et al., 2010; Friedman et al., 2016; Li et al., 2017) (Table 2). Here, KCNQ2 is linked to Anxiety.