In specific benign familial neonatal seizures mutations, loss of preferential targeting of Kv7.2/Kv7.3 channels on AIS (due to mutation in the ankyrin G binding motif at the C terminal) and axons can cause losses in their function and epilepsy (Chung et al., 2006). The gene discussed is KCNQ2; the disease is Benign familial neonatal seizures.