The use of bee venom to block SK activity has also been reported to cause an increase in basal dopamine levels in the striatum, which reduces motor deficits, prevents catalepsy symptoms, and causes a general increase in motor activity in PD mouse models (Alvarez and Sabatini, 2007; Chen et al., 2014; Maurice et al., 2015). The gene discussed is KCNN1; the disease is Parkinson disease.