In maternal immune activation and juvenile social isolation mouse models of schizophrenia, layer 5 PFC neurons had higher expression levels of SK3 channel (with no change in SK1 and SK2 expression levels), which cause depolarized cellular RMP, higher levels mAHP expression, and schizophrenia-related behavioral deficits (Mi et al., 2019). Here, KCNN2 is linked to schizophrenia.