IFNG and neoplasm: IFN-γ expression was detected to be approximately fourfold higher in l-1MTrp+CPA-treated mice than in vehicle-treated and l-1MTrp+PTX-treated mice (figure 2H), indicating the activation of cytotoxic T cell-mediated and natural killer cell-mediated antitumor immunity.22 The mRNA expression of the immune mediator stat1 (figure 2I) and effector molecule granzyme B (figure 2J), both of which are known to be responsive to IFN-γ treatment,23 24 was increased in the l-1MTrp+CPA-treated mice, leading to B16F10 tumor cell death.