LRRK2 and Parkinson disease: The cut off was set to 0.001, taking in account the prevalence of rare dominant diseases (1–2/10,000) and the MAF of the most frequent mutation associated with late onset PD p.(G2019S) in the LRRK2 gene, also known as rs34637584, which shows a MAF ranging from 0.001 to 0.0002 in different databases.