Moreover, considering that is well established that rare variants in LRRK2, PINK1, PARK2 and PARK7 genes have a higher prevalence in PD patients compared to healthy individuals [48–52], we analyzed the presence of at least one rare variant (MAF < 0.001) in patients and controls taking into account solely the 16 novel candidate genes. This evidence concerns the gene LRRK2 and Parkinson disease.