We first analysed the WES data (without applying any filter) of the 53 PD patients belonging to 26 families to search for mutations in genes already known to be associated to dominant form of PD such as, SNCA, VPS35 and LRRK2. Subsequently, we searched for large insertion/deletions in SNCA and LRRK2 genes by using MLPA approach. This evidence concerns the gene SNCA and Parkinson disease.