However, in contrast to fibrin-associated diffuse large B-cell lymphoma, our patient presented a profound immunosuppression with a disseminated disease, an EBV-associated HPS and an aggressive clinical course, suggesting that viral oncogenic mechanisms, including latent protein expression (such as LMP1), were determinant for the pathogenesis and clinical course of the disease. This evidence concerns the gene PDLIM7 and diffuse large B-cell lymphoma.