It is noteworthy that three probands (47, 48, and 49) were endowed with different homozygous variants, c.6299C>A p.(Ser2100*), c.7471_7472del p.(Ser2491Thrfs*5), and c.11410C>T p.(Arg3804*), respectively, in ALMS1, causing Alström syndrome (OMIM 203800) (Table 2). Here, ALMS1 is linked to Alstrom syndrome.