PSMB8 and Diarrhea: Besides, Y2 agonist PYY(3–36) administration had no effect on OA-induced diarrhoea although it was previously reported that PYY prevented faecal pellet output caused by dimethyl-PGE2 (Moriya et al. 2010) or inhibited propulsive colonic motor function through Y2 receptor in conscious mice (Wang et al. 2010).