PCGF1 and central nervous system cancer: Studies also showed that PCGF1 could promote cell cycle progression and proliferation in HeLa and SH-SY5Y tumour cells [21]; PCGF1 is highly expressed in glioma cells and stem cell-like glioma cells (SLCs) and promotes the U87 glioma cell proliferation, colony formation [34] and self-renewal abilities of SLCs [22].