ITGA4 and B-cell chronic lymphocytic leukemia: Similar results were obtained in an additional cohort of 104/119 TP53-wt CLL patients (Supplementary Fig. 2B), treated with FC in the UK CLL4 trial, where high CD49d expression, UM-IGHV genes and TL-IFR were, respectively, found in 52, 59 and 70 cases, all significantly associated with shorter PFS (see Supplementary Fig. 3D–F, Fig. 1E and Table 1).