ITGA4 and B-cell chronic lymphocytic leukemia: In detail, while neither TL nor CD49d expression had a prognostic impact in UM-IGHV CLL, the M-IGHV group could be significantly stratified by both TL (P = 0.002), and TL/CD49d combinations (P = 0.0014, Supplementary Table 4; P < 0.001, Fig. 1A–C).