In particular, TP53 disruption is known to blunt the apoptotic response to drugs, UM-IGHV genes are associated with increased pro-survival/proliferative signals through B-cell receptors, short telomeres, by driving genomic complexity, have a role in cell survival and proliferation history [14], and, finally, CD49d plays a critical role in CLL cell adhesion, migration back to proliferation sites and cell survival [15]. The gene discussed is ITGA4; the disease is B-cell chronic lymphocytic leukemia.