In particular, according to bivariate Cox proportional hazard models, CD49dpos cases in the M-IGHV subset associated with higher risk of disease progression compared to CD49dneg cases (HR = 2.49 (95% CI, [1.19–5.18], P = 0.015), whilst no additional prognostic information was provided when a high CD49d expression was tested in the context of UM-IGHV CLL (HR = 1.07 [95% CI, [0.71–1.61], P = 0.76) (Fig. 1A). The gene discussed is ITGA4; the disease is B-cell chronic lymphocytic leukemia.