Finally, despite the trend of the PFS curves indicating a detrimental effect of high CD49d expression in the TL-OFR group (HR = 1.73 [95% CI, 1.10–2.70], P = 0.017) but not in CLL patients with TL-IFR (HR = 1.09 [95% CI, 0.60–1.98], P = 0.78; Fig. 1C), no statistically significant interaction was documented between these variables (P = 0.20). This evidence concerns the gene ITGA4 and B-cell chronic lymphocytic leukemia.