ITGA4 and B-cell chronic lymphocytic leukemia: To take into account interactions between TL or CD49d with IGHV gene status, a multivariable model was generated to evaluate the independent prognostic impact of TL, CD49d expression and their combinations in the context of CLL with either UM-IGHV or M-IGHV gene status (Supplementary Table 4 and Fig. 1A–C).