The univariate Cox regression analysis showed that both the critical genes as S100A9, S100A8, NCF2, ITGAM, HK3, VNN2, PPBP, ITGB2 (Figure 8A), and co-expressed DElncRNA as ITGB2-AS1 (Figure 8B) are the risk factors affecting the prognosis of AML patients (P < 0.05). The gene discussed is HK3; the disease is acute myeloid leukemia.