Furthermore, we found that CYP1A1, CYP2B6, CYP3A4, UGT1A8, UGT2B11, UGT2B17, UGT2B7, XIST, SNHG6 were also well affected the chemotherapy or endocrine therapy drug sensitivities (which define as (1−AUC) in GDSC and define as [1−(AUC/30)] in CTRP) of antineoplastic drugs in pan-cancer cell lines according to GDSC and CTRP database; For example, CYP1A1, CYP2B6, CYP3A4, UGT2B11, UGT2B17, UGT2B7, XIST showed resistance to docetaxel, CYP1A1, CYP2B6, CYP3A4, UGT2B11, UGT2B17, XIST showed resistance to cisplatin, CYP2B6, UGT1A8, UGT2B11, XIST, SNHG6 showed resistance to abiraterone, and so on. Here, CYP3A4 is linked to cancer.