In addition, the proliferation of miR-29b-3p inhibitor-treated HCCLM3 cells transfected with sh-HCP5 was determined using BrdU assay, and the result showed that when treated with an miR-29b-3p inhibitor, the proliferative rate significantly increased (**p<0.01, Figure 6B), which indicated that miR-29b-3p was a tumor suppressor of HCC. This evidence concerns the gene HCP5 and hepatocellular carcinoma.