To validate the clinical relevance of our findings, we tested the effects of pharmacological stimulation of Kv11.1 on both TNBC (Fig. 5) and ER+ (supplementary Fig. 3A, 3B, 3C) patient-derived organoids (PDO) which recapitulate morphological and genetic features of the original tumor [[25], [26], [27]]. This evidence concerns the gene ESR1 and neoplasm.