Our analysis of ITGAE(CD103)+ T cells reveals an expression profile similar to CD8+ TRM cells in vitiligo,13 with 5 up-regulated genes that largely relate to cytotoxicity featuring in both datasets: GZMB, GNLY, NKG7, CCL5, and IFNG. Our data suggest that in health, CD8+ TRM cells express a homeostatic signature, including IL7R, but that in ICI-associated colitis, there is significant up-regulation of activation molecules and checkpoint molecules. Here, GNLY is linked to colitis.