Single-Cell RNA Sequencing Confirms Anti–CTLA-4/PD-1 Colitis Is Associated With High Proportions of Activated CD8+ Tissue Resident Memory T Cells That Express Transcripts for CTLA-4, PD-1, TIGIT, TIM-3, LAG-3, and Interferon-Gamma. The gene discussed is TIGIT; the disease is colitis.