We also showed that FTD-mutant hTau expression decreases the abundance of specific ribosomal proteins, with these effects becoming more severe the longer tau was present. Together, our findings reveal that ribosomal function is impaired in tauopathy; however, whether ribosomal function is similarly impaired in other neurodegenerative diseases remains to be determined. This evidence concerns the gene MAPT and frontotemporal dementia.