In our study, we found that DHM effectively triggered autophagy and subsequently inhibited the expression of fibrogenic or aHSC markers in a CCl4-induced mouse model of liver fibrosis in vivo and suppressed TGF-β1-induced HSCs activation in vitro (Fig. 3 and Additional file 2: Fig. S2). Here, TGFB1 is linked to Hepatic fibrosis.