GPT and metabolic dysfunction-associated steatotic liver disease: Another meta-analysis conducted in 2019 stated that this polymorphism had a major impact on the development of tissue damage in liver and that the G allele was considered as a risk factor for NAFLD in such a way that the ratio of development of the disease in those with one G allele to those without it was 1.88, and 4.01 in those where both alleles were G. It has also been suggested that this gene increases alanine aminotransferase levels in serum [50].