As both SNF2H and RSF1 are always overexpressed in the same cancer type, SNF2H has the function of maintaining the protein homeostasis of RSF1, and the protein level of SNF2H influences the interaction between RSF1 and other RSF1 binding proteins; thus, SNF2H inhibitors can be used in cancers with RSF1 overexpression, which provides a new treatment strategy for these kinds of cancers. The gene discussed is RSF1; the disease is cancer.