Whole-genome digital karyotype analysis has shown that the RSF1 and CCNE1 genes are co-amplified in OVCAR3 cells; RSF1 and cyclin E1 are co-upregulated in high-grade serous ovarian carcinoma, and a high prevalence of TP53mut (> 85%) also exists in high-grade serous ovarian carcinoma [68, 69]. Here, CCNE1 is linked to ovarian serous carcinoma.