The truncated RSF1 protein (aa 1–441) reduces tumorigenicity in mice with a TP53mut background suggesting that this truncated protein of RSF1 can be used as a therapeutic drug in TP53mut cancers to compete with RSF1 for interacting with cyclin E1 to inhibit the cancer-promoting functions of RSF1 [23] (Fig. 2f). Here, CCNE1 is linked to cancer.