RSF1 remodels the chromatin structure and generates regularly spaced nucleosome arrays, which are a component of interphase centromere proteins (CENPs) and are frequently found to be overexpressed and an adverse prognosticator in many types of cancers, including ovarian [7], breast [8], gallbladder [9], oral squamous cell [10], non-small-cell lung (NSCLC) [11], colon [12], nasopharyngeal cancer (NPC) [13], osteosarcoma (OS) [14], prostate cancer [15], bladder cancer (BC) [16], renal cell carcinoma [17], myxofibrosarcoma [18] and cervical cancer [19]. Here, CENPS is linked to hereditary clear cell renal cell carcinoma.