This was consistent with the fact that adequate maternal uterine perfusion through functional ETB-mediated vasodilation can be achieved in the heterozygous parents of sl/sl rat [63]; however, postnatal growth of sl/sl rat may later suffer the negative effect of HSCR-induced malnutrition and ETB−/−-mediated mesenteric hypoperfusion [1, 64]. This evidence concerns the gene EDNRB and nutritional deficiency disease.