In our research, Src was inhibited by miR-203a-3p, and EGFR activation and E-cadherin expression were inhibited; these findings are consistent with former results and indicate that hepatocytes promote high levels of PRL-3 expression in CRC cell MET through miR-203a-3p binding to Src and inhibiting EGFR activation. Here, PTP4A3 is linked to colorectal carcinoma.