Taking a functional approach based on chromosome conformation capture (3C) assays that were anchored at the IGFBP5 promoter, Wyszynski and colleagues identified a putative regulatory element centered on a structural variant (SV; esv3594306) that maps approximately 400 kb telomeric to IGFBP5. 14Allele-specific expression analyses and follow-up genotyping identified 14 highly correlated variants (all r2 > 0.8 with the top SNP, rs34005590) associated with breast cancer risk, which represent a third risk signal (OR = 0.82, p = 5.6 × 10−17).14 This evidence concerns the gene IGFBP5 and breast cancer.