Chromatin interaction methods implicate IGFBP5 (MIM: 146734) as the target gene at both loci11, 12, 13 and for the rs13387042 locus, eQTL analyses demonstrated association of the protective T-allele with slightly increased IGFBP5 levels in normal breast tissue11 and estrogen receptor-positive (ER+) breast cancers.12 The gene discussed is ESR1; the disease is breast cancer.