Although the current literature does not provide data on the impact of modified maternal nutrition during pregnancy and lactation on 5-HT2C and 5-HT2A receptors in the offspring brain, there are some reports indicating the effect of prolonged (15–20 weeks) feeding of adult male rodents a HFD (inducing obesity) on these receptors. This evidence concerns the gene HTR2C and obesity due to melanocortin 4 receptor deficiency.