MMP21 and coronary artery disorder: In recent years, many gene mutations have been confirmed to be related to abnormalities of left–right axis development in animal models, including ACVR2B, ZIC3, NODAL, LEFTY2, MMP21, SHROOM3, etc. In addition, an increasing number of cilia-related gene mutations have been confirmed to be closely related to CHD and laterality, such as Foxj1, Anks6, Bicc1, Tbc1d32 and Tbc1d32 [14–18], which also suggests that the disease has a genetics component.