As NF-κB [26], Wnt [27], p38 [28], JNK [28], and ERK1/2-MAPK [29, 30] pathways have the potential to be activated by lactate, we next investigated the activation of these pathways to confirm the mechanism of MIR17HG upregulation in lactate-stimulated CRC cells. Here, MAPK8 is linked to colorectal carcinoma.